Coyote vs. Acme follows Wile E. Coyote, who, after decades of suffering gruesome injuries from malfunctioning gadgets in his endless pursuit of the Road Runner, decides he has finally had enough. He resolves to fight back against his true tormentor: ACME Corporation, the profit-obsessed conglomerate that manufactures every faulty rocket skate, defective explosive, and broken magnet that has ever backfired on him.